IEEE ALIFE' 22 brings together researchers working on the emerging areas of Artificial Life and Complex Adaptive Systems, aiming to understand and synthesize life-like systems and applying bio-inspired synthetic methods to other science/engineering disciplines, including Biology, Robotics, Social Sciences, among others. Artificial Life is the study of the simulation and synthesis of living systems. In particular, this science of generalized living and life-like systems provides engineering with billions of years of design expertise to learn from and exploit through the example of the evolution of organic life on earth. Increased understanding of the massively successful design diversity, complexity, and adaptability of life is rapidly making inroads into all areas of engineering and the Sciences of the Artificial. Numerous applications of ideas from nature and their generalizations from life-as-we-know-it to life-as-it-could-be continually find their way into engineering and science.